Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Intracellular Ca(2+) signals constitute key elements in signal transduction. Of the three major Ca(2+) mobilizing messengers described, the most potent, nicotinic acid adenine dinucleotide phosphate (NAADP) is the least well understood in terms of its molecular targets [1]. Recently, we showed that...

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Bibliographic Details
Main Authors: Ruas, M, Rietdorf, K, Arredouani, A, Davis, L, Lloyd-Evans, E, Koegel, H, Funnell, T, Morgan, A, Ward, J, Watanabe, K, Cheng, X, Churchill, G, Zhu, M, Platt, F, Wessel, G, Parrington, J, Galione, A
Format: Journal article
Language:English
Published: 2010

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