The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.

A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved between different strains will be recognised by responding T-cells. We examined whether an invariant HLA-B8 restricted Nef₉₀₋₉₇ epitope FL8 shared...

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मुख्य लेखकों: Ranasinghe, SR, Kramer, H, Wright, C, Kessler, B, di Gleria, K, Zhang, Y, Gillespie, G, Blais, M, Culshaw, A, Pichulik, T, Simmons, A, Rowland-Jones, S, Mcmichael, A, Dong, T
स्वरूप: Journal article
भाषा:English
प्रकाशित: Public Library of Science 2011