Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Sanchez-Blanco, C, Clarke, F, Cornish, G, Depoil, D, Thompson, S, Dai, X, Rawlings, D, Dustin, M, Zamoyska, R, Cope, A, Purvis, H
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Elsevier 2018