In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors

In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors

<p>Zinc ion dependent β-lactamases (MBLs) catalyze the hydrolysis of almost all β-lactam antibiotics and resist the action of clinically available β-lactamase inhibitors. We report how application of <i>in silico</i> fragment-based molecular design employing thiol-mediated metal a...

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Dades bibliogràfiques
Autors principals:	Cain, R, Brem, J, Zollman, D, McDonough, M, Johnson, R, Spencer, J, Makena, A, Abboud, M, Cahill, S, Lee, S, McHugh, P, Schofield, C, Fishwick, C
Format:	Journal article
Idioma:	English
Publicat:	American Chemical Society 2017

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