Common coding variant in SERPINA1 increases the risk for large artery stroke

Common coding variant in SERPINA1 increases the risk for large artery stroke

Large artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genome-wide association studies. Here, we explore the role of coding variation in LAS by analyzing variants on the HumanExome BeadChip in a total of 3,127 cases and 9,778 controls from Europe, Australi...

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Main Authors: Malik, R, Dau, T, Gonik, M, Sivakumar, A, Deredge, D, Edeleva, E, Götzfried, J, Van Der Laan, S, Pasterkamp, G, Beaufort, N, Seixas, S, Bevan, S, Lincz, L, Holliday, E, Burgess, A, Rannikmäe, K, Minnerup, J, Kriebel, J, Waldenberger, M, Müller-Nurasyid, M, Lichtner, P, Saleheen, D, International Stroke Genetics Consortium, Rothwell, P, Levi, C, Attia, J, Sudlow, C, Braun, D, Markus, H, Wintrode, P, Berger, K, Jenne, D, Dichgans, M
Format: Journal article
Language:English
Published: National Academy of Sciences 2017

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