Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings

Antibiotic resistance tends to carry fitness costs, making it difficult to understand how resistance can be maintained in the absence of continual antibiotic exposure. Here we investigate this problem in the context of mcr-1, a globally disseminated gene that confers resistance to colistin, an agric...

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Detalhes bibliográficos
Principais autores: Ogunlana, L, Kaur, D, Shaw, LP, Jangir, P, Walsh, T, Uphoff, S, MacLean, RC
Formato: Journal article
Idioma:English
Publicado em: Springer Nature 2023