Tuning transcription factor availability through acetylation-mediated genomic redistribution

Tuning transcription factor availability through acetylation-mediated genomic redistribution

It is widely assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by diminishing occupancy of sequence-specific regulatory elements. However, in vivo transcription factors find their binding sites while confronted with a large excess of low-affinity dege...

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Detalles Bibliográficos
Autores principales: Louphrasitthiphol, P, Siddaway, R, Loffreda, A, Pogenberg, V, Friedrichsen, H, Schepsky, A, Faria-Shayler, P, Zeng, Z, Lu, M, Strub, T, Freter, R, Lisle, R, Suer, E, Thomas, B, Schuster-Boeckler, P, Filippakopoulos, P, Middleton, M, Lu, X, Patton, EE, Davidson, I, Lambert, J-P, Wilmanns, M, Steingrímsson, E, Mazza, D, Goding, C
Formato: Journal article
Lenguaje:English
Publicado: Cell Press 2020

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