PGBD5 promotes site-specific oncogenic mutations in human tumors

PGBD5 promotes site-specific oncogenic mutations in human tumors

Genomic rearrangements are a hallmark of human cancers. Here, we identify the piggyBac transposable element derived 5 (PGBD5) gene as encoding an active DNA transposase expressed in the majority of childhood solid tumors, including lethal rhabdoid tumors. Using assembly-based whole-genome DNA sequen...

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Bibliographic Details
Main Authors: Henssen, A, Koche, R, Zhuang, J, Jiang, E, Reed, C, Eisenberg, A, Still, E, MacArthur, I, Rodríguez-Fos, E, Gonzalez, S, Puiggròs, M, Blackford, A, Mason, C, de Stanchina, E, Gönen, M, Emde, A, Shah, M, Arora, K, Reeves, C, Socci, N, Perlman, E, Antonescu, C, Roberts, C, Steen, H, Mullen, E, Jackson, S, Torrents, D, Weng, Z, Armstrong, S, Kentsis, A
Format: Journal article
Language:English
Published: Springer Nature 2017

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