Systemic complement activation in age-related macular degeneration.

Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, paramete...

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Bibliographic Details
Main Authors: Scholl, H, Charbel Issa, P, Walier, M, Janzer, S, Pollok-Kopp, B, Borncke, F, Fritsche, L, Chong, V, Fimmers, R, Wienker, T, Holz, F, Weber, B, Oppermann, M
Format: Journal article
Language:English
Published: Public Library of Science 2008