Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2–3 randomised trial

<p>Background: There has been a significant change in trials methodology for solid tumours, in response to our greater understanding of cancer biology. FOCUS4 is a phase II/III trial programme testing targeted agents in patients with advanced colorectal cancer (CRC) in molecularly stratified c...

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Main Authors: Adams, R, Brown, E, Brown, L, Butler, R, Falk, S, Fisher, D, Kaplan, R, Quirke, P, Richman, S, Samuel, L, Seligmann, J, Seymour, M, Shiu, KK, Wasan, H, Wilson, R, Maughan, T
Format: Journal article
Published: Elsevier 2017