Hierarchical natural move Monte Carlo refines flexible RNA structures into cryo-EM densities

Ribonucleic acids (RNAs) play essential roles in living cells. Many of them fold into defined three-dimensional (3D) structures to perform functions. Recent advances in single-particle cryo-electron microscopy (cryo-EM) have enabled structure determinations of RNA to atomic resolutions. However, mos...

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Bibliographic Details
Main Authors: Chang, J-Y, Cui, Z, Yang, K, Huang, J, Minary, P, Zhang, J
Format: Journal article
Language:English
Published: Cold Spring Harbor Laboratory Press 2020