Molecular mechanism of BMP signal control by Twisted gastrulation

Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic development, kidney regeneration and cancer. We report crystal str...

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Bibliographic Details
Main Authors: Malinauskas, T, Moore, G, Rudolf, AF, Eggington, H, Belnoue-Davis, HL, El Omari, K, Griffiths, SC, Woolley, RE, Duman, R, Wagner, A, Leedham, SJ, Baldock, C, Ashe, HL, Siebold, C
Format: Journal article
Language:English
Published: Nature Research 2024