A simple method to cure established tumors by inflammatory killing of normal cells.

We describe a simple technology used to cure an established metastatic disease. Intradermal injection of plasmid DNA encoding a transcriptionally targeted cytotoxic gene, along with hsp70, not only promoted tissue-specific, inflammatory killing of normal melanocytes, but also induced a CD8(+) T-cell...

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Bibliographic Details
Main Authors: Daniels, G, Sanchez-Perez, L, Diaz, R, Kottke, T, Thompson, J, Lai, M, Gough, M, Karim, M, Bushell, A, Chong, H, Melcher, A, Harrington, K, Vile, R
Format: Journal article
Language:English
Published: 2004