DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-Goutières syndrome (AGS), but the mechanisms triggering disease in the human central nervous system (CNS) remain elusive. Here, we generated human models of AGS using genetically modified and patient-derived pluri...

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Bibliographic Details
Main Authors: Giordano, AMS, Luciani, M, Gatto, F, Abou Alezz, M, Beghè, C, Della Volpe, L, Migliara, A, Valsoni, S, Genua, M, Dzieciatkowska, M, Frati, G, Tahraoui-Bories, J, Giliani, SC, Orcesi, S, Fazzi, E, Ostuni, R, D'Alessandro, A, Di Micco, R, Merelli, I, Lombardo, A, Reijns, MAM, Gromak, N, Gritti, A, Kajaste-Rudnitski, A
Format: Journal article
Language:English
Published: Rockefeller University Press 2022

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