An ontogenetic switch drives the positive and negative selection of B cells

Developing B cells can be positively or negatively selected by self-antigens, but the mechanisms that determine these outcomes are incompletely understood. Here, we show that a B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to le...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Xu, X, Deobagkar-Lele, M, Bull, KR, Crockford, TL, Mead, A, Cribbs, AP, Sims, D, Anzilotti, C, Cornall, R
Format: Journal article
Sprache:English
Veröffentlicht: National Academy of Sciences 2020