An ontogenetic switch drives the positive and negative selection of B cells

An ontogenetic switch drives the positive and negative selection of B cells

Developing B cells can be positively or negatively selected by self-antigens, but the mechanisms that determine these outcomes are incompletely understood. Here, we show that a B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to le...

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Bibliografiske detaljer
Main Authors:	Xu, X, Deobagkar-Lele, M, Bull, KR, Crockford, TL, Mead, A, Cribbs, AP, Sims, D, Anzilotti, C, Cornall, R
Format:	Journal article
Sprog:	English
Udgivet:	National Academy of Sciences 2020

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