An ontogenetic switch drives the positive and negative selection of B cells

An ontogenetic switch drives the positive and negative selection of B cells

Developing B cells can be positively or negatively selected by self-antigens, but the mechanisms that determine these outcomes are incompletely understood. Here, we show that a B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to le...

書誌詳細
主要な著者:	Xu, X, Deobagkar-Lele, M, Bull, KR, Crockford, TL, Mead, A, Cribbs, AP, Sims, D, Anzilotti, C, Cornall, R
フォーマット:	Journal article
言語:	English
出版事項:	National Academy of Sciences 2020

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