CRISPR-Cas orthologues and variants: optimizing the repertoire, specificity and delivery of genome engineering tools
Robust and cost-effective genome editing in a diverse array of cells and model organisms is now possible thanks to the discovery of the RNA-guided endonucleases of the CRISPR-Cas system. The commonly used Cas9 of Streptococcus pyogenes shows high levels of activity but, depending on the application,...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Verlag
2017
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