Haplotype estimation for biobank-scale data sets
The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(N...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2016
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| _version_ | 1797050930165710848 |
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| author | O'Connell, J Sharp, K Shrine, N Wain, L Hall, I Tobin, M Zagury, J Delaneau, O Marchini, J |
| author_facet | O'Connell, J Sharp, K Shrine, N Wain, L Hall, I Tobin, M Zagury, J Delaneau, O Marchini, J |
| author_sort | O'Connell, J |
| collection | OXFORD |
| description | The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts. |
| first_indexed | 2024-03-06T18:12:30Z |
| format | Journal article |
| id | oxford-uuid:0380d180-f5a4-4967-9aec-c9c1698bddd3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:12:30Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:0380d180-f5a4-4967-9aec-c9c1698bddd32022-03-26T08:46:37ZHaplotype estimation for biobank-scale data setsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0380d180-f5a4-4967-9aec-c9c1698bddd3EnglishSymplectic Elements at OxfordNature Publishing Group2016O'Connell, JSharp, KShrine, NWain, LHall, ITobin, MZagury, JDelaneau, OMarchini, JThe UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method, SHAPEIT3, that can handle such biobank-scale data sets and results in switch error rates as low as ∼0.3%. The method exhibits O(NlogN) scaling with sample size N, enabling fast and accurate phasing of even larger cohorts. |
| spellingShingle | O'Connell, J Sharp, K Shrine, N Wain, L Hall, I Tobin, M Zagury, J Delaneau, O Marchini, J Haplotype estimation for biobank-scale data sets |
| title | Haplotype estimation for biobank-scale data sets |
| title_full | Haplotype estimation for biobank-scale data sets |
| title_fullStr | Haplotype estimation for biobank-scale data sets |
| title_full_unstemmed | Haplotype estimation for biobank-scale data sets |
| title_short | Haplotype estimation for biobank-scale data sets |
| title_sort | haplotype estimation for biobank scale data sets |
| work_keys_str_mv | AT oconnellj haplotypeestimationforbiobankscaledatasets AT sharpk haplotypeestimationforbiobankscaledatasets AT shrinen haplotypeestimationforbiobankscaledatasets AT wainl haplotypeestimationforbiobankscaledatasets AT halli haplotypeestimationforbiobankscaledatasets AT tobinm haplotypeestimationforbiobankscaledatasets AT zaguryj haplotypeestimationforbiobankscaledatasets AT delaneauo haplotypeestimationforbiobankscaledatasets AT marchinij haplotypeestimationforbiobankscaledatasets |