Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP)

Collagen degradation and proMMP-2 activation are major functions of MT1-MMP to promote cancer cell invasion. Since both processes require MT1-MMP homodimerization on the cell surface, herein we propose that the use of bifunctional inhibitors of this enzyme could represent an innovative approach to e...

Полное описание

Библиографические подробности
Главные авторы:	Cuffaro, D, Nuti, E, Gifford, V, Ito, N, Camodeca, C, Tuccinardi, T, Nencetti, S, Orlandini, E, Itoh, Y, Rossello, A
Формат:	Journal article
Язык:	English
Опубликовано:	Elsevier 2018

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