ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither

ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither

OBJECTIVE: To assess effects of intravenous streptokinase, one month of oral aspirin, or both, on long term survival after suspected acute myocardial infarction. DESIGN: Randomised, "2 x 2 factorial," placebo controlled trial. SETTING: 417 hospitals in 16 countries. SUBJECTS: 17 187 patie...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Baigent, C, Collins, R, Appleby, P, Parish, S, Sleight, P, Peto, R
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	BMJ Publishing Group 1998

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ISIS-2 - A LARGE RANDOMIZED TRIAL OF INTRAVENOUS STREPTOKINASE AND ORAL ASPIRIN IN ACUTE MYOCARDIAL-INFARCTION
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Cyhoeddwyd: (1989)

RANDOMIZED TRIAL OF HIGH-DOSE INTRAVENOUS STREPTOKINASE, OF ORAL ASPIRIN, AND OF INTRAVENOUS HEPARIN IN ACUTE MYOCARDIAL-INFARCTION
gan: Collins, R, et al.
Cyhoeddwyd: (1987)

Aspirin, heparin, and fibrinolytic therapy in suspected acute myocardial infarction.
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Cyhoeddwyd: (1997)

ISIS-3 and GISSI-2: no survival advantage with tissue plasminogen activator over streptokinase, but a significant excess of strokes with tissue plasminogen activator in both trials.
gan: Collins, R, et al.
Cyhoeddwyd: (1993)

Randomized factorial trial of high-dose intravenous streptokinase, of oral aspirin and of intravenous heparin in acute myocardial infarction. ISIS (International Studies of Infarct Survival) pilot study.
gan: Collins, R
Cyhoeddwyd: (1987)

Holter monitoring of ventricular arrhythmias in a randomised, controlled study of intravenous streptokinase in acute myocardial infarction.
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Cyhoeddwyd: (1991)

RANDOMIZED FACTORIAL TRIAL OF HIGH-DOSE INTRAVENOUS STREPTOKINASE, OF ORAL ASPIRIN, AND OF INTRAVENOUS HEPARIN IN ACUTE MYOCARDIAL-INFARCTION
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Cyhoeddwyd: (1987)

INTRAVENOUS STREPTOKINASE FOR ACUTE MYOCARDIAL-INFARCTION - REPLY
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Cyhoeddwyd: (1983)

AFTER ISIS-3 - REPLY
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Cyhoeddwyd: (1992)

Immediate aspirin for suspected ischaemic stroke.
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Cyhoeddwyd: (1999)

ISIS-3 - A RANDOMIZED COMPARISON OF STREPTOKINASE VS TISSUE PLASMINOGEN-ACTIVATOR VS ANISTREPLASE AND OF ASPIRIN PLUS HEPARIN VS ASPIRIN ALONE AMONG 41,299 CASES OF SUSPECTED ACUTE MYOCARDIAL-INFARCTION
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Significant reduction in mortality with streptokinase given 7-24 hours after pain onset.
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ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group.
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REDUCTION IN INFARCT SIZE, ARRHYTHMIAS, CHEST PAIN AND MORBIDITY BY EARLY INTRAVENOUS BETA-BLOCKADE IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION
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Cyhoeddwyd: (1983)

Early intravenous atenolol treatment in suspected acute myocardial infarction.
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Cyhoeddwyd: (1981)

RANDOMIZED CONTROLLED TRIAL OF STREPTOKINASE, ASPIRIN, AND COMBINATION OF BOTH IN TREATMENT OF ACUTE ISCHEMIC STROKE
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REDUCTION IN INFARCT SIZE, ARRHYTHMIAS AND CHEST PAIN BY EARLY INTRAVENOUS BETA-BLOCKADE IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION
gan: Yusuf, S, et al.
Cyhoeddwyd: (1983)

Reduction in infarct size, arrhythmias and chest pain by early intravenous beta blockade in suspected acute myocardial infarction.
gan: Yusuf, S, et al.
Cyhoeddwyd: (1983)

MORNING PEAK IN THE INCIDENCE OF MYOCARDIAL-INFARCTION - EXPERIENCE IN THE ISIS-2 TRIAL
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Effect of intravenous streptokinase on acute myocardial infarction: pooled results from randomized trials.
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Cyhoeddwyd: (1982)

ISIS-4 - REPLY
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Cyhoeddwyd: (1995)

Clinical effects of anticoagulants in suspected acute myocardial infarction - Reply
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Cyhoeddwyd: (1997)

Effects of streptokinase in patients presenting within 6 hours of prolonged chest pain with ST segment depression.
gan: Collins, R, et al.
Cyhoeddwyd: (1995)

ISIS-2 - 4-YEAR MORTALITY FOLLOW-UP OF 17,187 PATIENTS AFTER FIBRINOLYTIC AND ANTIPLATETLET THERAPY IN SUSPECTED ACUTE MYOCARDIAL-INFARCTION
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Cyhoeddwyd: (1993)

Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomised trials.
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Cyhoeddwyd: (1991)

Early intravenous atenolol treatment in suspected acute myocardial infarction. Preliminary report of a randomised trial.
gan: Yusuf, S, et al.
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Benefit of heparin plus aspirin vs aspirin alone in unstable angina.
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ISIS COLLABORATIVE GROUP - RANDOMIZED TRIAL OF EARLY IV ATENOLOL IN MYOCARDIAL-INFARCTION - SUBSIDIARY ANALYSES
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ISIS-3 - REPLY
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Cyhoeddwyd: (1991)

REDUCTION IN INFARCT SIZE, ARRHYTHMIAS AND MORBIDITY BY EARLY INTRAVENOUS BETA BLOCKADE
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Cyhoeddwyd: (1982)

Side Effects of Intravenous Streptokinase in Different Age Groups Patients with Acute Myocardial Infarction
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Cyhoeddwyd: (2014-02-01)

Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials.
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Cigarette smoking, tar yields, and non-fatal myocardial infarction: 14,000 cases and 32,000 controls in the United Kingdom. The International Studies of Infarct Survival (ISIS) Collaborators.
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Benefit of aspirin plus angiotensin-converting enzyme inhibitor.
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Early intravenous beta-blockade in myocardial infarction.
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The International Stroke Trial (IST): A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke
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REDUCTION IN INFARCT SIZE AND MORBIDITY BY EARLY INTRAVENOUS BETABLOCKADE
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REDUCTION IN INFARCT SIZE, MORBIDITY AND SHORT-TERM MORTALITY BY EARLY INTRAVENOUS BETABLOCKADE
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Anti-streptokinase antibody inhibition of streptokinase induced fibrinolysis following intra-pleural streptokinase
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The entry ECG in the early diagnosis and prognostic stratification of patients with suspected acute myocardial infarction.
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