Modulation of compartmentalized cyclic nucleotide signalling via local inhibition of phosphodiesterase activity
Cyclic nucleotides phosphodiesterases (PDEs) are the only enzymes that degrade the cyclic nucleotides cAMP and cGMP and play a key role in modulating the amplitude and duration of the signal delivered by these two key intracellular second messengers. Defects in cyclic nucleotide signalling are kn...
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| Format: | Journal article |
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MDPI
2016
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