Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles

A highly regio-, diastereo- and enantioselective Cu-catalyzed desymmetrization of diverse meso-bisphosphates with alkyl zirconium nucleophiles has been developed. The reaction tolerates functional groups incompatible with many common organometallic reagents and provides access to a broad range of fu...

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Detalles Bibliográficos
Autores principales: Jacques, R, Pullin, R, Fletcher, S
Formato: Journal article
Publicado: Springer Nature 2019