Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles

A highly regio-, diastereo- and enantioselective Cu-catalyzed desymmetrization of diverse meso-bisphosphates with alkyl zirconium nucleophiles has been developed. The reaction tolerates functional groups incompatible with many common organometallic reagents and provides access to a broad range of fu...

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Bibliographic Details
Main Authors: Jacques, R, Pullin, R, Fletcher, S
Format: Journal article
Published: Springer Nature 2019