Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents
SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal coronavirus antibodies and compare the rate of anti...
| Principais autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Elsevier
2023
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| _version_ | 1826313134807187456 |
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| author | Ratcliffe, H Tiley, K Longet, S Tonry, C Roarty, C Watson, C Amirthalingam, G Vichos, I Morey, E Douglas, NL Marinou, S Plested, E Aley, PK Galiza, E Faust, SN Hughes, S Murray, C Roderick, MR Shackley, F Oddie, S Lee, TWR Turner, DPJ Raman, M Owens, S Turner, PJ Cockerill, H Lopez Bernal, J Ijaz, S Poh, J Shute, J Linley, E Borrow, R Hoschler, K Brown, KE Carroll, MW Klenerman, P Dunachie, SJ Ramsay, M Voysey, M Waterfield, T Snape, MD |
| author_facet | Ratcliffe, H Tiley, K Longet, S Tonry, C Roarty, C Watson, C Amirthalingam, G Vichos, I Morey, E Douglas, NL Marinou, S Plested, E Aley, PK Galiza, E Faust, SN Hughes, S Murray, C Roderick, MR Shackley, F Oddie, S Lee, TWR Turner, DPJ Raman, M Owens, S Turner, PJ Cockerill, H Lopez Bernal, J Ijaz, S Poh, J Shute, J Linley, E Borrow, R Hoschler, K Brown, KE Carroll, MW Klenerman, P Dunachie, SJ Ramsay, M Voysey, M Waterfield, T Snape, MD |
| author_sort | Ratcliffe, H |
| collection | OXFORD |
| description | SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal coronavirus antibodies and compare the rate of antibody decline for nucleocapsid and spike protein in serum and oral fluid against SARS-CoV-2 within the pediatric population. No differences in seasonal coronaviruses antibody concentrations were found at baseline between cases and controls, suggesting no protective effect from pre-existing immunity against seasonal coronaviruses. Antibodies against seasonal betacoronaviruses were boosted in response to SARS-CoV-2 infection. In serum, anti-nucleocapsid antibodies fell below the threshold of positivity more quickly than anti-spike protein antibodies. These findings add to our understanding of protection against infection with SARS-CoV-2 within the pediatric population, which is important when considering pediatric SARS-CoV-2 immunization policies. |
| first_indexed | 2024-09-25T04:08:17Z |
| format | Journal article |
| id | oxford-uuid:04b3d0c0-d730-487c-a37f-bfd7bced0a4a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:08:17Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:04b3d0c0-d730-487c-a37f-bfd7bced0a4a2024-06-11T11:31:51ZSerum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescentsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:04b3d0c0-d730-487c-a37f-bfd7bced0a4aEnglishSymplectic ElementsElsevier2023Ratcliffe, HTiley, KLonget, STonry, CRoarty, CWatson, CAmirthalingam, GVichos, IMorey, EDouglas, NLMarinou, SPlested, EAley, PKGaliza, EFaust, SNHughes, SMurray, CRoderick, MRShackley, FOddie, SLee, TWRTurner, DPJRaman, MOwens, STurner, PJCockerill, HLopez Bernal, JIjaz, SPoh, JShute, JLinley, EBorrow, RHoschler, KBrown, KECarroll, MWKlenerman, PDunachie, SJRamsay, MVoysey, MWaterfield, TSnape, MDSARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal coronavirus antibodies and compare the rate of antibody decline for nucleocapsid and spike protein in serum and oral fluid against SARS-CoV-2 within the pediatric population. No differences in seasonal coronaviruses antibody concentrations were found at baseline between cases and controls, suggesting no protective effect from pre-existing immunity against seasonal coronaviruses. Antibodies against seasonal betacoronaviruses were boosted in response to SARS-CoV-2 infection. In serum, anti-nucleocapsid antibodies fell below the threshold of positivity more quickly than anti-spike protein antibodies. These findings add to our understanding of protection against infection with SARS-CoV-2 within the pediatric population, which is important when considering pediatric SARS-CoV-2 immunization policies. |
| spellingShingle | Ratcliffe, H Tiley, K Longet, S Tonry, C Roarty, C Watson, C Amirthalingam, G Vichos, I Morey, E Douglas, NL Marinou, S Plested, E Aley, PK Galiza, E Faust, SN Hughes, S Murray, C Roderick, MR Shackley, F Oddie, S Lee, TWR Turner, DPJ Raman, M Owens, S Turner, PJ Cockerill, H Lopez Bernal, J Ijaz, S Poh, J Shute, J Linley, E Borrow, R Hoschler, K Brown, KE Carroll, MW Klenerman, P Dunachie, SJ Ramsay, M Voysey, M Waterfield, T Snape, MD Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents |
| title | Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents |
| title_full | Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents |
| title_fullStr | Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents |
| title_full_unstemmed | Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents |
| title_short | Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents |
| title_sort | serum hcov spike specific antibodies do not protect against subsequent sars cov 2 infection in children and adolescents |
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