Unusual antigen presentation offers new insight into HIV vaccine design
Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide ran...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2017
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| _version_ | 1797051193426444288 |
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| author | McMichael, A Picker, L |
| author_facet | McMichael, A Picker, L |
| author_sort | McMichael, A |
| collection | OXFORD |
| description | Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses. |
| first_indexed | 2024-03-06T18:16:27Z |
| format | Journal article |
| id | oxford-uuid:04c75f52-722e-415a-8487-709a7f8355f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:16:27Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:04c75f52-722e-415a-8487-709a7f8355f42022-03-26T08:53:36ZUnusual antigen presentation offers new insight into HIV vaccine designJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:04c75f52-722e-415a-8487-709a7f8355f4EnglishSymplectic Elements at OxfordElsevier2017McMichael, APicker, LRecent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses. |
| spellingShingle | McMichael, A Picker, L Unusual antigen presentation offers new insight into HIV vaccine design |
| title | Unusual antigen presentation offers new insight into HIV vaccine design |
| title_full | Unusual antigen presentation offers new insight into HIV vaccine design |
| title_fullStr | Unusual antigen presentation offers new insight into HIV vaccine design |
| title_full_unstemmed | Unusual antigen presentation offers new insight into HIV vaccine design |
| title_short | Unusual antigen presentation offers new insight into HIV vaccine design |
| title_sort | unusual antigen presentation offers new insight into hiv vaccine design |
| work_keys_str_mv | AT mcmichaela unusualantigenpresentationoffersnewinsightintohivvaccinedesign AT pickerl unusualantigenpresentationoffersnewinsightintohivvaccinedesign |