Defective interferon gamma production by tumor-specific cd8+ T cells is associated with 5′methylcytosine-guanine hypermethylation of interferon gamma promoter
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship be...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Frontiers Media
2020
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