Synthesis, Serum Stability and Cell Uptake of Cyclic and Hairpin Decoy Oligonucleotides for TCF/LEF and GLI Transcription Factors
A series of hairpin oligonucleotides bearing a 5′-alkyne and 3′-azide were cyclised using the CuAAC reaction to form cyclic decoys for targeting the DNA binding site of the TCF/LEF and GLI transcription factors. Incubation of a fluorescent hairpin oligomer and its cyclic analogue in fetal calf serum...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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