Neonatal diabetes caused by homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensititvity markedly affect diabetes risk
<p><em>Aims/hypothesis</em> The pancreatic ATP-sensitive potassium (KATP) channel plays a pivotal role in linking beta cell metabolism to insulin secretion. Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congen...
| Hlavní autoři: | , , , , , , , |
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| Médium: | Journal article |
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Springer International Publishing AG
2016
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