Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.
We develop a model of tyrosine phosphorylation and activation of the T-cell receptor (TCR) by localization to regions of close membrane-membrane proximity (close contact) that physically exclude tyrosine phosphatases such as CD45. Phosphatase exclusion generates regions of low phosphatase and high k...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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