WNT signalling control by KDM5C during development affects cognition

Although KDM5C is one of the most frequently mutated genes in X-linked intellectual disability, the exact mechanisms that lead to cognitive impairment remain unknown. Here we use human patient-derived induced pluripotent stem cells and Kdm5c knockout mice to conduct cellular, transcriptomic, chromat...

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Détails bibliographiques
Auteurs principaux: Karwacki-Neisius, V, Jang, A, Cukuroglu, E, Tai, A, Jiao, A, Predes, D, Yoon, J, Brookes, E, Chen, J, Iberg, A, Halbritter, F, Õunap, K, Gecz, J, Schlaeger, TM, Ho Sui, S, Göke, J, He, X, Lehtinen, MK, Pomeroy, SL, Shi, Y
Format: Journal article
Langue:English
Publié: Springer Nature 2024