Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.

The hyaluronan (HA)-binding function (lectin function) of the leukocyte homing receptor, CD44, is tightly regulated. Herein we address possible mechanisms that regulate CD44 isoform-specific HA binding. Binding studies with melanoma transfectants expressing CD44H, CD44E, or with soluble immunoglobul...

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Bibliographic Details
Main Authors: Bennett, K, Modrell, B, Greenfield, B, Bartolazzi, A, Stamenkovic, I, Peach, R, Jackson, D, Spring, F, Aruffo, A
Format: Journal article
Language:English
Published: 1995