A mechanism of release of calreticulin from cells during apoptosis.

Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone responsible for glycoprotein folding and Ca(2+) homeostasis. CRT also has extracellular functions, e.g. tumor and apoptotic cell recognition and wound healing, but the mechanism of CRT extracellular release is unknown. Cytosolic localizat...

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Bibliographic Details
Main Authors: Tarr, J, Young, P, Morse, R, Shaw, D, Haigh, R, Petrov, P, Johnson, S, Winyard, P, Eggleton, P
Format: Journal article
Language:English
Published: 2010