Asymmetric synthesis of (-)-martinellic acid.

A high-yielding total asymmetric synthesis of (-)-martinellic acid is reported. The conjugate addition of lithium (R)-N-allyl-N-(α-methyl-4-methoxybenzyl)amide to tert-butyl (E)-3-[2'-(N,N-diallylamino)-5'-bromophenyl]propenoate and alkylation of the resultant β-amino ester have been used...

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Bibliographic Details
Main Authors: Davies, S, Fletcher, A, Lee, J, Lorkin, T, Roberts, P, Thomson, J
Format: Journal article
Language:English
Published: 2013