HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

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This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice w...

Bibliográfalaš dieđut
Váldodahkkit:	Chen, R, Ogunshola, O, Yeoh, K, Jani, A, Papadakis, M, Nagel, S, Schofield, C, Buchan, A
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2014

Geahča maid

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
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Regulation of HIF: prolyl hydroxylases.
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Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
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Cerebral blood flow alteration in neuroprotection following cerebral ischaemia.
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Almmustuhtton: (2011)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia
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Almmustuhtton: (2011)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
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Almmustuhtton: (2003)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
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Almmustuhtton: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
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Almmustuhtton: (2003)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
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Almmustuhtton: (2011)

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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
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Almmustuhtton: (2010)

Therapeutic manipulation of the HIF hydroxylases.
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Almmustuhtton: (2010)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
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Almmustuhtton: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
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Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
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Almmustuhtton: (2004)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
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Almmustuhtton: (2016)

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Almmustuhtton: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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Almmustuhtton: (2016)

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
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Almmustuhtton: (2021)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
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Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Dahkki: Yeoh, K, et al.
Almmustuhtton: (2013)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
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Almmustuhtton: (2013)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
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USE OF PROLYL HYDROXYLASE INHIBITORS TO INDUCE HIF-RELATED METABOLIC CHANGES AND INCREASE C-KIT EXPRESSION IN CARDIOSPHERE-DERIVED CELLS
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Almmustuhtton: (2011)

Inhibition of a viral prolyl hydroxylase
Dahkki: Langley, G, et al.
Almmustuhtton: (2019)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
Dahkki: Astuti, D, et al.
Almmustuhtton: (2010)

Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia.
Dahkki: Nagel, S, et al.
Almmustuhtton: (2012)

Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
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Almmustuhtton: (2017-05-01)

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
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Almmustuhtton: (2018)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
Dahkki: Holt-Martyn, JP, et al.
Almmustuhtton: (2019)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
Dahkki: Lippl, K
Almmustuhtton: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
Dahkki: Masson, N, et al.
Almmustuhtton: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
Dahkki: Takahiro Kambara, et al.
Almmustuhtton: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
Dahkki: Kiichi Hirota
Almmustuhtton: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Dahkki: Kilian B. Kennel, et al.
Almmustuhtton: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
Dahkki: Savyuk, Maria Olegovna, et al.
Almmustuhtton: (2021-05-01)