A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.

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OBJECTIVE: Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pa...

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Bibliographic Details
Main Authors: Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I
Format: Journal article
Language:English
Published: 2013

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