Downregulation of the Na(+)-creatine cotransporter in failing human myocardium and in experimental heart failure.
BACKGROUND:The failing myocardium is characterized by depletion of phosphocreatine and of total creatine content. We hypothesized that this is due to loss of creatine transporter protein. METHODS AND RESULTS:Creatine transporter protein was quantified in nonfailing and failing human myocardium (expl...
المؤلفون الرئيسيون: | Neubauer, S, Remkes, H, Spindler, M, Horn, M, Wiesmann, F, Prestle, J, Walzel, B, Ertl, G, Hasenfuss, G, Wallimann, T |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
1999
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مواد مشابهة
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Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism.
حسب: Spindler, M, وآخرون
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Myocardial creatine uptake is regulated by the sarcolemmal fraction of the creatine transporter, but not by the total creatine transporter pool
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New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle.
حسب: Walzel, B, وآخرون
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Chronic high-dose creatine feeding does not attenuate left ventricular remodeling in rat hearts post-myocardial infarction.
حسب: Horn, M, وآخرون
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Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine.
حسب: Boehm, E, وآخرون
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