Interleukin-1 beta and interleukin-6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro.

It has previously been shown that the cytokines interleukin-1 beta and interleukin-6 (IL-1 beta and IL-6) stimulate directly the release of corticotrophin-releasing-hormone-41 from the rat hypothalamus in vitro, while IL-1 beta can also stimulate the release of somatostatin. These effects can be ant...

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Bibliographic Details
Main Authors: Navarra, P, Pozzoli, G, Brunetti, L, Ragazzoni, E, Besser, M, Grossman, A
Format: Journal article
Language:English
Published: 1992