Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.

The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) T-cell responses restricted by two closely related HLA class I alleles, B*5701 and B*5703, tha...

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Detalles Bibliográficos
Autores principales:	Yu, X, Lichterfeld, M, Chetty, S, Williams, K, Mui, S, Miura, T, Frahm, N, Feeney, M, Tang, Y, Pereyra, F, Labute, M, Pfafferott, K, Leslie, A, Crawford, H, Allgaier, R, Hildebrand, W, Kaslow, R, Brander, C, Allen, T, Rosenberg, E, Kiepiela, P, Vajpayee, M, Goepfert, P, Altfeld, M, Goulder, P
Formato:	Journal article
Lenguaje:	English
Publicado:	2007

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.

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