Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

The 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are targets for treatment of anaemia and other ischaemia related diseases. PHD inhibitors are in clinical trials; however, the number of reported templates for PHD inhibition is limited. We report structure–...

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Detalhes bibliográficos
Main Authors: Holt-Martyn, J, Tumber, A, Rahman, M, Lippl, K, Figg, W, McDonough, M, Chowdhury, R, Schofield, C
Formato: Journal article
Publicado em: Royal Society of Chemistry 2019