Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
The 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are targets for treatment of anaemia and other ischaemia related diseases. PHD inhibitors are in clinical trials; however, the number of reported templates for PHD inhibition is limited. We report structure–...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2019
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