Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
The 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (PHDs) are targets for treatment of anaemia and other ischaemia related diseases. PHD inhibitors are in clinical trials; however, the number of reported templates for PHD inhibition is limited. We report structure–...
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Bibliographic Details
| Main Authors: |
Holt-Martyn, J,
Tumber, A,
Rahman, M,
Lippl, K,
Figg, W,
McDonough, M,
Chowdhury, R,
Schofield, C |
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| Format: | Journal article
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| Published: |
Royal Society of Chemistry
2019
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