MSH3 promotes back-up DNA end-joining pathways that sustain the survival of BRCA2- deficient cells
DNA repair pathways that maintain genomic stability are essential in avoiding carcinogenesis. However, inactivation of these repair pathways frequently occurs during tumorigenesis and cancer cells become dependent on alternative mechanisms for DNA repair. Cancer cells with heterozygous germline muta...
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| Format: | Thesis |
| Language: | English |
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2022
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