Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

<h4>Objective</h4> <p>Patients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with IBD, but neither the significance nor the functional mechanism of this association is clear. We studied bacte...

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Bibliographic Details
Main Authors:	Schwerd, T, Pandey, S, Yang, H, Bagola, K, Jameson, E, Jung, J, Lachmann, R, Shah, N, Patel, S, Booth, C, Runz, H, Düker, G, Bettels, R, Rohrbach, M, Kugathasan, S, Chapel, H, Keshav, S, Elkadri, A, Platt, N, Muise, A, Koletzko, S, Xavier, R, Marquardt, T, Powrie, F, Wraith, J, Gyrd-Hansen, M, Platt, F, Uhlig, H
Format:	Journal article
Language:	English
Published:	BMJ Publishing Group 2016

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

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