The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.

The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.

Glycosylation of macrolide antibiotics confers host cell immunity from endogenous and exogenous agents. The Streptomyces antibioticus glycosyltransferases, OleI and OleD, glycosylate and inactivate oleandomycin and diverse macrolides including erythromycin, respectively. The structure of these enzym...

Полное описание

Библиографические подробности
Главные авторы:	Bolam, D, Roberts, S, Proctor, MR, Turkenburg, J, Dodson, E, Martinez-Fleites, C, Yang, M, Davis, B, Davies, G, Gilbert, H
Формат:	Journal article
Язык:	English
Опубликовано:	2007

Схожие документы

Probing the breadth of macrolide glycosyltransferases: in vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency.
по: Yang, M, и др.
Опубликовано: (2005)

Pathogen- and Host-Directed Anti-Inflammatory Activities of Macrolide Antibiotics
по: Helen C. Steel, и др.
Опубликовано: (2012-01-01)

Voltammetric study of the partitioning of macrolide antibiotics at the water/nitrobenzene interface. Relationship to the pharmacokinetic profiling of macrolides
по: Zoran Mandic
Опубликовано: (2014-09-01)

Macrolide antibiotic therapy in patients with cystic fibrosis
по: MH Schöni
Опубликовано: (2003-05-01)

Administration of macrolide antibiotics increases cardiovascular risk
по: Yang Wu, и др.
Опубликовано: (2023-02-01)

Degradation of macrolide antibiotic in water by heterogeneous photocatalysis
по: A. Ounnar, и др.
Опубликовано: (2017-12-01)

Functional and informatics analysis enables glycosyltransferase activity prediction
по: Yang, M, и др.
Опубликовано: (2018)

Inhibiting Effect of Macrolide Polyene Antibiotics on Reproduction of Viruses
по: A. A. Bagirova, и др.
Опубликовано: (2020-05-01)

Context-specific action of macrolide antibiotics on the eukaryotic ribosome
по: Maxim S. Svetlov, и др.
Опубликовано: (2021-05-01)

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
по: Andrew C. Pawlowski, и др.
Опубликовано: (2018-01-01)

Sugar mimetics: Multicomponent glycosyltransferase inhibitors
по: Lucas, R, и др.
Опубликовано: (2005)

Eritrea's blueprint for trachoma elimination: A home-grown model for sustainable impact
по: Gilbert Baayenda, и др.
Опубликовано: (2025-03-01)

The provident planner : a blueprint for homes, communities and lifestyles /
по: 363971 Rasbach, Roger
Опубликовано: (1976)

Association of Macrolide Resistance Genotypes and Synergistic Antibiotic Combinations for Combating Macrolide-Resistant MRSA Recovered from Hospitalized Patients
по: Amr S. Bishr, и др.
Опубликовано: (2021-07-01)

Autoinducer Analogs Can Provide Bactericidal Activity to Macrolides in <i>Pseudomonas aeruginosa</i> through Antibiotic Tolerance Reduction
по: Mizuki Abe, и др.
Опубликовано: (2021-12-01)

Addition of macrolide antibiotics for hospital treatment of community-acquired pneumonia
по: Wei, J, и др.
Опубликовано: (2024)

Mechanism of Action of Macrolide Antibiotic Filipin on Cell and Lipid Membranes
по: A. A. Samedova, и др.
Опубликовано: (2020-05-01)

Scaffold Modifications in Erythromycin Macrolide Antibiotics. A Chemical Minireview
по: Kjell Undheim
Опубликовано: (2020-08-01)

Research on the treatment of Pseudomonas aeruginosa pneumonia in children by macrolide antibiotics
по: Huang Xu-qiang, и др.
Опубликовано: (2015-01-01)

Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli.
по: Ho Young Lee, и др.
Опубликовано: (2007-02-01)

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
по: Bertrand Beckert, и др.
Опубликовано: (2021-07-01)

Additional corticosteroids or alternative antibiotics for the treatment of macrolide-resistant pneumonia
по: Eun-Ae Yang, и др.
Опубликовано: (2017-08-01)

Examining the role of macrolides and host immunity in combatting filarial parasites
по: Doug S. Carithers
Опубликовано: (2017-04-01)

Structural dissection and high-throughput screening of mannosylglycerate synthase.
по: Flint, J, и др.
Опубликовано: (2005)

A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
по: Lucia García-López, и др.
Опубликовано: (2021-11-01)

How to read electrical blueprints /
по: 219560 Heine, Gilbert M., и др.
Опубликовано: (1954)

Phenotypic Resistance of (MRSA) Clinical Isolates to Some Macrolide Antibiotic Groups
по: Ali Yaseen, и др.
Опубликовано: (2023-12-01)

Molecular Imprinted Polymers for Macrolides, Aminoglycosides and Some Other Biosynthetic Antibiotics
по: M. I. Yakhkind, и др.
Опубликовано: (2020-05-01)

In Vitro Impact of Macrolide Antibiotics on the Viability of Selected Mammalian Cell Lines
по: Eva Tvrdá, и др.
Опубликовано: (2023-09-01)

Mechanisms of Resistance to Macrolide Antibiotics among <i>Staphylococcus aureus</i>
по: Maria Miklasińska-Majdanik
Опубликовано: (2021-11-01)

Macrolide antibiotics activate the integrated stress response and promote tumor proliferation
по: Xin Yu, и др.
Опубликовано: (2023-03-01)

Macrolide antibiotics and their place in therapy of upper respiratory tract infections therapy
по: A. Y. Ovchinnikov, и др.
Опубликовано: (2016-12-01)

Differential trypanocidal activity of novel macrolide antibiotics; correlation to genetic lineage.
по: Carolina Aquilino, и др.
Опубликовано: (2012-01-01)

Place of Semisynthetic Penicillins and Macrolides in Antibiotic Therapy for Respiratory Infections in Children
по: A.Ye. Abaturov, и др.
Опубликовано: (2014-09-01)

Blueprint
по: Fariba Jaffary
Опубликовано: (2023-03-01)

Engineering of cyclodextrin glycosyltransferase /
по: Dijkhuizen, L.

Effector glycosyltransferases in Legionella
по: Yury eBelyi, и др.
Опубликовано: (2011-04-01)

Increase in Pneumococcus Macrolide Resistance, USA
по: Lauri A. Hicks, и др.
Опубликовано: (2010-05-01)

Clinical efficacy of macrolide antibiotics in mycoplasma pneumoniae pneumonia carrying a macrolide-resistant mutation in the 23 S rRNA gene in pediatric patients
по: Mengyuan He, и др.
Опубликовано: (2024-07-01)

Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase.
по: Lee, S, и др.
Опубликовано: (2011)