A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.

A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.

Null alleles of the gene encoding NEMO (NF-kappaB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typically cause a syndrome of immune deficiency and ectodermal dysplasia. Here we describe an allele of Ikbkg in mice that impaired Toll-like receptor signaling,...

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Bibliographic Details
Main Authors: Siggs, O, Berger, M, Krebs, P, Arnold, C, Eidenschenk, C, Huber, C, Pirie, E, Smart, N, Khovananth, K, Xia, Y, McInerney, G, Karlsson Hedestam, G, Nemazee, D, Beutler, B
Format: Journal article
Language:English
Published: 2010

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