Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis.

We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentivi...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Alton, E, Beekman, J, Boyd, A, Brand, J, Carlon, M, Connolly, M, Chan, M, Conlon, S, Davidson, H, Davies, J, Davies, L, Dekkers, J, Doherty, A, Gea-Sorli, S, Gill, D, Griesenbach, U, Hasegawa, M, Higgins, T, Hironaka, T, Hyndman, L, McLachlan, G, Inoue, M, Hyde, S, Innes, J, Maher, T, Moran, C, Meng, C, Paul-Smith, M, Pringle, I, Pytel, K, Rodriguez-Martinez, A, Schmidt, A, Stevenson, B, Sumner-Jones, S, Toshner, R, Tsugumine, S, Wasowicz, M, Zhu, J
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	BMJ Publishing Group 2016

Ижил төстэй зүйлс

Preparation for a first-in-man lentivirus trial in cystic fibrosis patients
-н: Griesenbach, U, зэрэг
Хэвлэсэн: (2016)

Moving lentiviral-based gene therapy into a first-in-man CF trial
-н: Griesenbach, D, зэрэг
Хэвлэсэн: (2015)

Towards a first-in-human trial with a pseudotyped lentivirus
-н: Alton, EW, зэрэг
Хэвлэсэн: (2020)

Production of SIV-F/HN: a new Lentivirus vector for CF gene therapy
-н: Hyde, S, зэрэг
Хэвлэсэн: (2015)

Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy.
-н: Griesenbach, U, зэрэг
Хэвлэсэн: (2012)

ASSESSMENT OF F/HN-PSEUDOTYPED LENTIVIRUS AS A CLINICALLY RELEVANT VECTOR FOR LUNG GENE THERAPY
-н: Griesenbach, U, зэрэг
Хэвлэсэн: (2012)

ASSESSMENT OF F/HN-PSEUDOTYPED LENTIVIRUS IN A CLINICALLY RELEVANT VECTOR FOR LUNG GENE THERAPY
-н: Griesenbach, U, зэрэг
Хэвлэсэн: (2012)

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung.
-н: Alton, E, зэрэг
Хэвлэсэн: (2014)

Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung
-н: Alton, E, зэрэг
Хэвлэсэн: (2014)

Lentivirus gene therapy for autoimmune pulmonary alveolar proteinosis
-н: Palau, H, зэрэг
Хэвлэсэн: (2019)

The lung as a factory to produce secreted intrapulmonary and circulatory proteins
-н: Paul-Smith, M, зэрэг
Хэвлэсэн: (2017)

Cumulative CFTR expression following repeated aerosol delivery of non-viral pGM169/GL67A formulation to mouse lung
-н: Alton, E, зэрэг
Хэвлэсэн: (2012)

REPEAT ADMINISTRATION OF GL67A/PGM169 IS FEASIBLE, SAFE, AND PRODUCES ENDOGENOUS LEVELS OF CFTR EXPRESSION AFTER 12 DOSES
-н: Alton, E, зэрэг
Хэвлэсэн: (2012)

Lentivirus GM-CSF gene therapy for autoimmune pulmonary alveolar proteinosis
-н: Lund-Palau, H, зэрэг
Хэвлэсэн: (2018)

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins
-н: Paul-Smith, M, зэрэг
Хэвлэсэн: (2018)

Lentivirus GM-CSF gene therapy ameliorates autoimmune pulmonary alveolar proteinosis
-н: Lund-Palau, H, зэрэг
Хэвлэсэн: (2018)

Recombinant Sendai virus vector to evaluate vector distribution in a large animal model of lung gene transfer
-н: McLachlan, G, зэрэг
Хэвлэсэн: (2004)

Pre-existing immunity to human parainfluenza virus (hPIV) does not affect rSIV.F/HN-mediated transduction efficiency
-н: Pytel, K, зэрэг
Хэвлэсэн: (2016)

Development of an immunocytochemical assay to detect human CFTR expression following gene therapy
-н: Davidson, H, зэрэг
Хэвлэсэн: (2008)

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.
-н: McLachlan, G, зэрэг
Хэвлэсэн: (2011)

TOXICOLOGY STUDIES IN SUPPORT OF THE UK CF GENE THERAPY CONSORTIUM'S MULTI-DOSE CLINICAL TRIAL
-н: Griesenbach, U, зэрэг
Хэвлэсэн: (2011)

Caprine lentivirus in sheep milk and semen
-н: C.C.V. Lima, зэрэг

An immunocytochemical assay to detect human CFTR expression following gene transfer.
-н: Davidson, H, зэрэг
Хэвлэсэн: (2009)

Low levels of CFTR gene transfer with F/HN pseudotyped lentivirus are sufficient to generate ion transport correction in airway cell cultures from cystic fibrosis patients
-н: Sergijenko, A, зэрэг
Хэвлэсэн: (2020)

Genetic medicines for CF: Hype versus reality
-н: Alton, E, зэрэг
Хэвлэсэн: (2016)

A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution.
-н: Gifford, R, зэрэг
Хэвлэсэн: (2008)

OPTIMISATION OF MOLECULAR ASSAYS FOR CLINICAL TRIAL OF GL67A/PDNA DELIVERY TO NOSE AND LUNG OF CF PATIENTS
-н: Sumner-Jones, S, зэрэг
Хэвлэсэн: (2009)

Gene therapy for respiratory diseases; progress and a changing context
-н: Alton, EWFW, зэрэг
Хэвлэсэн: (2020)

DEVELOPMENT, PRODUCTION AND EVALUATION OF CLINICAL GRADE CFTR EXPRESSION PLASMID FOR CF LUNG GENE THERAPY
-н: Gill, DR, зэрэг
Хэвлэсэн: (2010)

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep
-н: Alton, E, зэрэг
Хэвлэсэн: (2013)

The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.
-н: Alton, E, зэрэг
Хэвлэсэн: (2013)

Discovery and analysis of the first endogenous lentivirus
-н: Katzourakis, A, зэрэг
Хэвлэсэн: (2007)

Discovery and analysis of the first endogenous lentivirus.
-н: Katzourakis, A, зэрэг
Хэвлэсэн: (2007)

EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CYSTIC FIBROSIS: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY''
-н: Davies, J, зэрэг
Хэвлэсэн: (2009)

EVALUATION OF SAFETY AND GENE EXPRESSION WITH A SINGLE DOSE OF PGM169/GL67A ADMINISTERED TO THE NOSE AND LUNG OF INDIVIDUALS WITH CF: THE UK CF GENE THERAPY CONSORTIUM "PILOT STUDY"
-н: Davies, J, зэрэг
Хэвлэсэн: (2009)

SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CYSTIC FIBROSIS
-н: Davies, G, зэрэг
Хэвлэсэн: (2011)

SAFETY AND EXPRESSION OF A SINGLE DOSE OF LIPID-MEDIATED CFTR GENE THERAPY TO THE UPPER AND LOWER AIRWAYS OF PATIENTS WITH CF
-н: Davies, J, зэрэг
Хэвлэсэн: (2011)

A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis
-н: Alton, E, зэрэг
Хэвлэсэн: (2013)

Update on the UK CF Gene Therapy Consortium Multidoes, non-viral, gene therapy trial
-н: Alton, E, зэрэг
Хэвлэсэн: (2012)

A randomised, double-blind, placebo-controlled phase IIB clinical trial of repeated application of gene therapy in patients with cystic fibrosis.
-н: Alton, E, зэрэг
Хэвлэсэн: (2013)