Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.

Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.

AIMS: Delta-like ligand 4 (DLL4) is one of five known Notch ligands in mammals and interacts predominantly with Notch 1. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative...

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Bibliographic Details
Main Authors:	Martinez, J, Müller, M, Turley, H, Steers, G, Choteau, L, Li, J, Sainson, R, Harris, A, Pezzella, F, Gatter, K
Format:	Journal article
Language:	English
Published:	2009

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