Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.

Genetic analysis of hypertrophic cardiomyopathy (HCM), a mendelian form of cardiac hypertrophy, indicates that the primary defect is in sarcomeric function. However, the initial proposal that depressed myocardial contraction leads to a 'compensatory' hypertrophy has proven inconsistent wit...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Ashrafian, H, Redwood, C, Blair, E, Watkins, H
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2003

Eitemau Tebyg

Myocardial dysfunction in hypertrophic cardiomyopathy.
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Ascertainment strategies and genotype:phenotype correlations in hypertrophic cardiomyopathy.
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Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy
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The genetics of hypertrophic cardiomyopathy: Teare redux.
gan: Watkins, H, et al.
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Functional analysis of hypertrophic cardiomyopathy missense mutations in the light meromyosin region of beta myosin heavy chain
gan: Redwood, C, et al.
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Inherited cardiomyopathies.
gan: Watkins, H, et al.
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Inherited cardiomyopathies.
gan: Watkins, H, et al.
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Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy.
gan: Ashrafian, H, et al.
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Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.
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Mutations in the gamma2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.
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Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name?
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Hypertrophic cardiomyopathy mutations in the gamma 2 subunit of AMP-activated kinase suggest a central role of energy compromise in disease pathogenesis
gan: Blair, E, et al.
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Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.
gan: Elliott, K, et al.
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Linked genetic modifiers in hypertrophic cardiomyopathy
gan: Ektisham, J, et al.
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Investigation of troponin I mutations causing familial hypertrophic cardiomyopathy
gan: Abdulrazzak, H, et al.
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Correlates of myocardial fibrosis in hypertrophic cardiomyopathy
gan: Kramer, CM, et al.
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Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres
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Early onset malignant hypertrophic cardiomyopathy caused by mutations in MYBPC3
gan: Carballo, S, et al.
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Sudden death in hypertrophic cardiomyopathy.
gan: Watkins, H
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Altered inhibitory and troponin C-binding activities in cardiac troponin I mutants known to cause hypertrophic cardiomyopathy
gan: Elliott, K, et al.
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Novel mutations in cardiac MYBPC3 and early onset malignant hypertrophic cardiomyopathy
gan: Carballo, S, et al.
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Delineating the role of adenosine monophosphate (AMP)-activated protein kinase (AMP) gamma 2 subunit in hypertrophic cardiomyopathy (HCM)
gan: Grignani, R, et al.
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Comparison of the functional effects of mutations in troponin T which cause dilated and hypertrophic cardiomyopathies
gan: Robinson, P, et al.
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Identification of myocardial disarray in patients with hypertrophic cardiomyopathy and ventricular arrhythmias
gan: Ariga, R, et al.
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Mutations of the light meromyosin domain of the beta-myosin heavy chain rod in hypertrophic cardiomyopathy.
gan: Blair, E, et al.
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Novel mutations in cardiac MYBPC3 causing early onset malignant hypertrophic cardiomyopathy
gan: Carballo, S, et al.
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Diffusion tensor magnetic resonance imaging of myocardial disarray in hypertrophic cardiomyopathy
gan: Ariga, R, et al.
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Is DNA testing for hypertrophic cardiomyopathy cost-effective?
gan: Wordsworth, S, et al.
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Mutations in cis can confound genotype-phenotype correlations in hypertrophic cardiomyopathy.
gan: Blair, E, et al.
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Double mutations in CIS can confound genotype-phenotype correlations in hypertrophic cardiomyopathy
gan: Blair, E, et al.
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Novel mutations in cardiac MYPBC3 cause early onset malignant hypertrophic cardiomyopathy (HCM)
gan: Carballo, S, et al.
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Progression of myocardial fibrosis in hypertrophic cardiomyopathy: mechanisms and clinical implications
gan: Raman, B, et al.
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Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy.
gan: Karamitsos, T, et al.
Cyhoeddwyd: (2013)

METABOLIC ALTERATION IN HYPERTROPHIC CARDIOMYOPATHY (METAL-HCM STUDY): RANDOMISED DOUBLE BLINDED PLACEBO CONTROLLED TRIAL OF PERHEXILINE THERAPY IN PATIENT WITH HYPERTROPHIC CARDIOMYOPATHY
gan: Abozguia, K, et al.
Cyhoeddwyd: (2010)

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
gan: Robinson, P, et al.
Cyhoeddwyd: (2007)

Impaired left ventricular energy metabolism in hypertrophic cardiomyopathy is not due to fibrosis.
gan: Petersen, SE, et al.
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HYPERTROPHIC CARDIOMYOPATHY AND MYOCARDIAL CRYPT OF THE LEFT VENTRICLE
gan: Yu. V. Frolova, et al.
Cyhoeddwyd: (2017-02-01)

A novel mutation in phospholamban causes a mixed hypertrophic and dilated cardiomyopathy phenotype with autosomal dominant inheritance
gan: Carballo, S, et al.
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Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing.
gan: Ashrafian, H, et al.
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DEVELOPMENT AND CHARACTERISATION OF A NOVEL KNOCK-IN MODEL OF PRKAG2 CARDIOMYOPATHY
gan: Yavari, A, et al.
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