Deoxyguanosine is a TLR7 agonist

Deoxyguanosine is a TLR7 agonist

Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imid...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Davenne, T, Bridgeman, A, Rigby, R, Rehwinkel, J
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Wiley 2019

Παρόμοια τεκμήρια

Comparison of human B cell activation by TLR7 and TLR9 agonists
ανά: Neys Lori, κ.ά.
Έκδοση: (2008-07-01)

The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants
ανά: Shaik Mohammad Naushad, κ.ά.
Έκδοση: (2023-08-01)

Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer.
ανά: Nikunj M Shukla, κ.ά.
Έκδοση: (2012-01-01)

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8.
ανά: Xiaoyu Wang, κ.ά.
Έκδοση: (2022-01-01)

The TLR7 agonist Imiquimod promote the immunogenicity of msenchymal stem cells
ανά: Li Zhang, κ.ά.
Έκδοση: (2015-01-01)

PNP inhibitors selectively kill cancer cells lacking SAMHD1
ανά: Tamara Davenne, κ.ά.
Έκδοση: (2020-11-01)

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant
ανά: Deepender Kaushik, κ.ά.
Έκδοση: (2020-08-01)

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
ανά: Vasilakos John P, κ.ά.
Έκδοση: (2007-10-01)

Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope
ανά: Maryam Mashhadi Abolghasem Shirazi, κ.ά.
Έκδοση: (2023-10-01)

Varicella-Zoster virus ORF9 Is an antagonist of the DNA sensor cGAS
ανά: Hertzog, J, κ.ά.
Έκδοση: (2020)

Determining 8-oxo-2’-deoxyguanosine/2’-deoxyguanosine ratio in DNA by reverse phase HPLC combined with amperometric detection
ανά: D. S. Esipov, κ.ά.
Έκδοση: (2010-06-01)

Synthesis of 8-oxo-7,8-dihydro-2′-deoxyguanosine from 2′-deoxyguanosine using Cu(II)/H2O2/ascorbate: A new strategy for an improved yield
ανά: Patrícia S. Peres, κ.ά.
Έκδοση: (2016-06-01)

Genomic 8-oxo-7,8-dihydro-2&#39;-deoxyguanosine Quantification
ανά: Antonio Sarno
Έκδοση: (2013-09-01)

Interferon induction held captive in tumor cells
ανά: Bridgeman, A, κ.ά.
Έκδοση: (2021)

Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists.
ανά: Anne Månsson Kvarnhammar, κ.ά.
Έκδοση: (2013-01-01)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
ανά: Jinghua Sun, κ.ά.
Έκδοση: (2012-01-01)

Electrophilic Substitution at C(7) of a Protected 7-Deaza-2’-deoxyguanosine – The 2’-Deoxyribonucleoside Parent Analogue of Queuosine #
ανά: Helmut Rosemeyer, κ.ά.
Έκδοση: (2007-04-01)

Lignin-chitosan-based biocomposite film for the localized delivery of TLR7 agonist imiquimod
ανά: Aashna Jassal, κ.ά.
Έκδοση: (2024-11-01)

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine
ανά: Sehui Kim, κ.ά.
Έκδοση: (2023-09-01)

A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist
ανά: Huju Chi, κ.ά.
Έκδοση: (2022-06-01)

8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development
ανά: Sandra K. Urbaniak, κ.ά.
Έκδοση: (2020-01-01)

Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
ανά: Hertzog, J, κ.ά.
Έκδοση: (2022)

Viruses transfer the antiviral second messenger cGAMP between cells
ανά: Bridgeman, A, κ.ά.
Έκδοση: (2015)

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist
ανά: Craig L Slingluff, κ.ά.
Έκδοση: (2021-05-01)

A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models
ανά: Bethany Crouse, κ.ά.
Έκδοση: (2023-07-01)

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
ανά: Verena Turco, κ.ά.
Έκδοση: (2023-02-01)

Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides
ανά: Chun Wu
Έκδοση: (2016-01-01)

Mitochondrial deoxyguanosine kinase is required for female fertility in mice
ανά: Gao Yake, κ.ά.
Έκδοση: (2024-02-01)

1161 Development of TLR7- and STING-conjugatable agonists for immunostimulatory ADC-based cancer therapies
ανά: Fabienne Vernejoul, κ.ά.
Έκδοση: (2023-11-01)

8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress
ανά: T. S. Nevredimova, κ.ά.
Έκδοση: (2014-10-01)

Sequence-Dependent Variation in the Reactivity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine toward Oxidation
ανά: Lim, Kok Seong, κ.ά.
Έκδοση: (2014)

Formulated Phospholipids as Non-Canonical TLR4 Agonists
ανά: Hong Liang, κ.ά.
Έκδοση: (2022-11-01)

The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)
ανά: Golding, B, κ.ά.
Έκδοση: (1997)

Deoxyguanosine kinase deficiency: natural history and liver transplant outcome
ανά: Manzoni, E, κ.ά.
Έκδοση: (2024)

Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
ανά: Varshney, Dhruv, κ.ά.
Έκδοση: (2022)

Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
ανά: Varshney, Dhruv, κ.ά.
Έκδοση: (2021)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers
ανά: Joseph F. Grippo, κ.ά.
Έκδοση: (2021-07-01)

Identifying the Tautomeric Form of a Deoxyguanosine-Estrogen Quinone Intermediate
ανά: Douglas E. Stack
Έκδοση: (2015-09-01)

Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists
ανά: Linda K. Curtiss, κ.ά.
Έκδοση: (2012-10-01)

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
ανά: Katherine A. Michaelis, κ.ά.
Έκδοση: (2019-10-01)