Deoxyguanosine is a TLR7 agonist

Deoxyguanosine is a TLR7 agonist

Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imid...

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Dettagli Bibliografici
Autori principali:	Davenne, T, Bridgeman, A, Rigby, R, Rehwinkel, J
Natura:	Journal article
Lingua:	English
Pubblicazione:	Wiley 2019

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