The dynamics of signal triggering in a gp130-receptor complex.
gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containi...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797051711067521024 |
|---|---|
| author | Matadeen, R Hon, W Heath, J Jones, E Fuller, S |
| author_facet | Matadeen, R Hon, W Heath, J Jones, E Fuller, S |
| author_sort | Matadeen, R |
| collection | OXFORD |
| description | gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade. |
| first_indexed | 2024-03-06T18:23:21Z |
| format | Journal article |
| id | oxford-uuid:071102a9-9ea3-4c34-a4d7-29154580c9e3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:23:21Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:071102a9-9ea3-4c34-a4d7-29154580c9e32022-03-26T09:05:43ZThe dynamics of signal triggering in a gp130-receptor complex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:071102a9-9ea3-4c34-a4d7-29154580c9e3EnglishSymplectic Elements at Oxford2007Matadeen, RHon, WHeath, JJones, EFuller, Sgp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 A resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade. |
| spellingShingle | Matadeen, R Hon, W Heath, J Jones, E Fuller, S The dynamics of signal triggering in a gp130-receptor complex. |
| title | The dynamics of signal triggering in a gp130-receptor complex. |
| title_full | The dynamics of signal triggering in a gp130-receptor complex. |
| title_fullStr | The dynamics of signal triggering in a gp130-receptor complex. |
| title_full_unstemmed | The dynamics of signal triggering in a gp130-receptor complex. |
| title_short | The dynamics of signal triggering in a gp130-receptor complex. |
| title_sort | dynamics of signal triggering in a gp130 receptor complex |
| work_keys_str_mv | AT matadeenr thedynamicsofsignaltriggeringinagp130receptorcomplex AT honw thedynamicsofsignaltriggeringinagp130receptorcomplex AT heathj thedynamicsofsignaltriggeringinagp130receptorcomplex AT jonese thedynamicsofsignaltriggeringinagp130receptorcomplex AT fullers thedynamicsofsignaltriggeringinagp130receptorcomplex AT matadeenr dynamicsofsignaltriggeringinagp130receptorcomplex AT honw dynamicsofsignaltriggeringinagp130receptorcomplex AT heathj dynamicsofsignaltriggeringinagp130receptorcomplex AT jonese dynamicsofsignaltriggeringinagp130receptorcomplex AT fullers dynamicsofsignaltriggeringinagp130receptorcomplex |